Nontraditional roles of angiotensin-converting enzyme.
نویسندگان
چکیده
Many articles have described the biochemistry of the renin-angiotensin system (RAS). Simply put, renin and angiotensin-converting enzyme (ACE) produce angiotensin II, which affects the brain (increased thirst), the gut (increased salt absorption), the adrenals (aldosterone production), the kidneys (salt and water retention), the heart (increased cardiac output), and vascular smooth muscle (vasoconstriction). Inhibitors of ACE and the angiotensin II type 1 receptor are now widely used to reduce blood pressure and to treat hypertension, heart failure, and renal disease. The effectiveness of these drugs and abundant data from animal models show that the RAS is the body’s central mechanism for regulating blood pressure. Modern studies of the RAS have substantially broadened the known roles of this system by showing that angiotensin II influences cellular proliferation and the inflammatory response. Although this wider interpretation of the RAS encompasses more than control of blood pressure, it still focuses on the effects of angiotensin II in the context of vascular injury. This increased understanding of the RAS inevitably leads to the question of whether, even now, we fully understand all of the physiological roles of the RAS. Here, we argue that the answer is no, that nature uses the components of the RAS and, in particular, ACE for a wide variety of physiological tasks.
منابع مشابه
Serum Angiotensin Converting Enzyme in Patients with Psoriasis
Background: Controversial data concerning the elevation of serum angiotensin-converting enzyme in psoriasis are reported in the literature. In order to verify whether this abnormality exists in Iranian patients, we performed this study. Method: Serum angiotensin-converting enzyme level was measured in 40 psoriatics. According to clinical forms of psoriasis, patients were further divided into th...
متن کاملInhibitors of Angiotensin-converting Enzyme or Blockers of Angiotensin-2 Receptor in COVID-19 Patients with Comorbid Cardiovascular or Pulmonary Diseases
Following the skyrocketing spread of SARS-CoV-2 into almost all the countries over five continents, diverse clinical strategies are urgently needed to defeat its pandemic, considering that an magic-bullet antiviral vaccine or treatment is presently unavailable. WHO later proclaimed the viral outbreak as a pandemic. Despite this fast speed of the pandemic, any recommended treatment must first...
متن کاملP23: The Effects of Captopril, as Angiotensin Converting Enzyme Inhibitor, on LPS-Induced Systemic Inflammation
It has been shown that the renin-angiotensin system (RAS) plays key roles in the inflammation process. Imbalance in the oxidant-antioxidant system is one of the major causes of inflammation. In the present study, the effects of captopril on total and differential WBC, oxidative stress in systemic inflammation produced by lipopolysaccharide (LPS) were investigated. The rats were divided to: cont...
متن کاملThe host’s angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections
The number of victims of the COVID-19 pandemic shows important geographical differences. In this study, a number of human genetic polymorphisms were compared to the number of Covid-19 patients and Covid-19 mortality. Data from 33 countries were analyzed. Among the polymorphisms tested, the human angiotensine converting enzyme (ACE) polymorphism turned out to be a determinant factor in both prev...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Hypertension
دوره 59 4 شماره
صفحات -
تاریخ انتشار 2012